Multi-ingredient targeted nutritional intervention in sarcopenic older adults: A double-blind randomized controlled trial.

Nasrin Nasimi


Sarcopenia, age-related loss of skeletal muscle mass, strength and performance, is growing considerably among elderly population and becomes a major public health concern. Nutritional intervention is considered as an effective approach to manage sarcopenia and prevent its related disability. This study aimed to evaluate the efficacy of multi-ingredient targeted yogurt fortification without exercise training on muscle mass and functionality in older adults with sarcopenia. After screening 500 community-dwelling older adults, 66 eligible sarcopenic elderly (low muscle mass, handgrip strength and/or gait speed) were randomly assigned into two groups: Intervention group who received daily beta-Hydroxy beta-Methyl Butyrate and vitamin D-fortified yogurt (3g HMB, 1000IU D3) and control group who received daily plain yogurt for 12 weeks. Body composition was measured by dual-energy X-ray absorptiometry (DXA). Muscle strength and physical performance were evaluated by hydraulic handgrip dynamometer and 4-m gait speed. Nutritional status, physical activity and health-related quality of life were also assessed using validated questionnaire.

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