N-Aryl 2-Cyanothioacetamide Intermediates in Heterocyclic Synthesis: Synthesis and AntimicrobialEvaluation of 3-Cyano 2(1H)-Pyridineth-Ione, Chromene-3-Carbothioamide and Chromeno[3,4c]Pyridinethione Derivatives

MA Salem, HK Thabet, MA Ism

Abstract

A novel synthesis of 3-cyano-2(1H)-pyridinethiones, chromene-3-carbothioamide and chromeno[3,4-c]pyridines were obtained through interaction of N-aryl cyanothioacetamide derivatives with some electrophilic reagents. Most of the target compounds were then evaluated for their antimicrobial and antifungal activities.