Novel thiourea, quinazoline, thiazolidine, thieno[2,3-d]-pyrimidine, 4-thiazolidinone, pyrrole, pyrrolo[2,3-d]pyrimidine derivatives containing sulfamoyl moiety

E. M. Ahmed , N. M. Taha, S. M

Abstract

4-Isothiocyanato-N-(2,6-dimethoxypyrimidin-4-yl)benzenesulf-onamide (2) was used as starting material for the synthesis of some novel carbamothioates (3a,b), 1,2,4-triazole (4), 2- thioxothiazolidin-4-one (5), quinazolinone (6), thieno[2,3-d]pyrimidine (11), benzi-midazole (17) derivatives, the non-isolated adduct (19) was used as key intermediate to synthesize some novel 4-aminothiazole (20) and 4-thiazolidinone (22) derivatives to evaluate their anti tumor activity