Research Article
Marsida Krasniqi and Ahmed Abd
Abstract
Background: To detect any ocular surface changes with Sofosbuvir in Egyption patients with hepatitis C virus. Design: Continuous audit over 3 months for patients enrolled for Sofosbuvir therapy. Participants: A total of 100 Egyptian Chronic hepatitis C patients enrolled for Sofosbuvir therapy, Egypt, from January 2018 to March 2018. Methods: Ocular history. Ocular examination including: Visual acuity measurement. Slit-lamp bio microscopy of the ocular surface. Schirmer’s test: To exclude dry eye, Break up time test, Conjunctival impression cytology. Main outcome measures: After the treatment, BUT and Schirmer test declined from 13.08 second and 14.47 mm to 6.4 second and 7.98 mm respectively. Regarding impression cytology, the mean N/C ratio decreased from 0.66 to 0.57 while squamous metablasia and keratinization was found in 16% of patients post treatment. It was also found that 44% were complaining of dry eye symptoms after the treatment. Conclusion: Our study detected ocular surface changes after three months of sofosbuvir treatment for HCV.