Oxidative coupling of thiols to disulfides using two trimethylammonium halochromates (VI), (CH3)3NH[CrO3X], (X= F,Cl) supported on alumina

Fahmideh Shabani1, Shahriare G

Abstract

Mild and efficient method for the oxidative coupling of thiols by alumina supported trimethylammonium fluorochromate (TriMFC) and trimethylammonium chlorochromate (TriMCC) are reported.Alumina supported trimethylammonium fluorochromate and trimethylammonium chlorochromate are efficient and new reagents, which prepared easily and oxidized thiols to the corresponding disulfides quickly. The reactions performed cleanly and controlled to stop at the disulfide stage without overoxidation side products. The easy procedure, simple work-up, short reaction times, and excellent yields are another advantages of these reagents.