Commentary
Benjamin W. Y. Lo and Hitos
Abstract
This commentary summarizes and updates current evidence regarding pathophysiologic mechanisms of brain somatic interactions in aneurysmal subarachnoid hemorrhage. It discusses primary and secondary injurious processes after aneurysmal rupture. It reviews current state of knowledge of multi-organ involvement in this disease condition, including brain-cardiopulmonary, neuroendocrine and renal manifestations. Emerging evidence is also summarized regarding brain-gastrointestinal, immune and hematologic systems.