Persistent Hypocalcemia in a Premature Neonate Exposed to Topiramate In-Utero

Roia Katebian, Pamela Nicoski,

Abstract

Neonatal hypocalcemia can result from numerous etiologies and is commonly seen in premature neonates. We describe a late preterm neonate with asymptomatic hypocalcemia whose mother took topiramate throughout the entire pregnancy. Other factors that may contribute to hypocalcemia, including infant of a diabetic mother, were ruled out in our patient. The patient we are reporting on required calcium supplementation for persistent hypocalcemia most likely due to fetal topiramate exposure.

Relevant Publications in Journal of Neonatal Biology