Pin1-catalyzed conformational regulation as a common oncogenic signaling mechanism and a unique drug target

Short Communication

Xiao Zhen Zhou


 A focal regular flagging instrument in a considerable lot of these pathways is proline-coordinated phosphorylation, which is managed by numerous kinases and phosphatases. The structure and capacity of these phosphorylated proteins are additionally constrained by a solitary proline isomerase: PIN1. PIN1 is overactivated in malignant growths and it advances disease and malignant growth undifferentiated cells by upsetting the equalization of oncogenes and tumor silencers. 

Relevant Publications in Journal of Translational Research