Research Article
Abdullah Şenlikci, Env
Abstract
Numerous studies conducted within the last decade regarding the clinical use of prognostic systems based on systemic inflammation in patients with different types of cancer have suggested that these systems can be used in predicting the postoperative survival in cancer patients and for classifying patients before operation. In this study, prognostic value of thrombocytosis and neutrophil/lymphocyte ratio in gastric cancer patients after surgical resection was assessed retrospectively cancer patients after surgical resection was assessed retrospectively. The patient’s files and electronic data of 121 patients who underwent resection due to gastric cancer were retrospectively examined. The effects of the COP, NLR and COPNLR classifications on survival were investigated as well. In addition; tumour localisation, tumour histological type, the extent of tumour differentiation, vascular and lymphatic invasion, CEA level, haemoglobin level, tumour depth, lymph node status, lymph node metastasis, n-ratio, CA19.9 level, perineural invasion, lymph node metastasis and tumour size were assessed with respect to COP-NLR classification. No statistically significant differences were observed when the effects of tumour localisation histological type, the extent of differentiation, vascular and lymphatic invasion, CEA level, haemoglobin level, tumour depth and lymph node status on survival were assessed with respect to COP-NLR classification (p>0.005). Assessment of lymph node metastasis, n-ratio, CA19.9 level and mortality according to the COP-NLR classification revealed a statistically significant difference (p<0.005). A statistically significant difference was observed when effect of perineural invasion, lymph node metastasis, tumour size, n-ratio and CA 19.9 on survival were assessed (p<0.005). A statistically significant difference was also observed when the effect of thrombocyte count on survival was assessed (p<0.005). A statistically significant difference was observed when the effect of thrombocyte count on survival was assessed (p<0.005). A statistically significant difference was identified between the median survival times of the cases with respect to COPNLR classes (p<0.001). Tumour type, tumour size, perineural invasion, lymph node metastasis, n-ratio, Ca 19-9 level, thrombocytosis and the neutrophil/lymphocyte ratio have an effect on survival. COP-NLR classification can be used to estimate survival.