Rapid one-pot four component synthesis of bioactive pyranopyrazoles using citric acid as a mild organocatalyst

P. B. Pawara, S. D. Jadhava, B

Abstract

An efficient one-pot multicomponent synthesis of pyranopyrazoles from aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate in the presence of citric acid as a highly effective organocatalyst is reported. This method offers good yield, clean reaction, short reaction time, and easy purification of product.