Release Kinetics of Cellulosic Nano particulate Formulation for Oral Administration of an Antiviral Drug: Effect of Process and Formulation variables

Deep R Naik, Anand J Patel

Abstract

Release Kinetics of Cellulosic Nano particulate Formulation forOral Administration of anAntiviral Drug: Effect of Process and Formulation variables Recently, researchers have increasing interest in cellulosic polymers for optimizing the efficiency of existing drugs utilizing better-designed drug delivery systems. In the present research nanoparticles were prepared using cellulose esters to obtain a drug product with a good oral bioavailability and biological half life. Acyclovir (ACY) was formulated by combining the modified solvent evaporation/extraction technique, sonicator and high pressure homogenization approaches. Various formulation parameters such as sonication-time, concentration of cellulose esters and surfactants were studied. Nanoparticles were obtained with enhanced encapsulation efficiency, negatively charged, defined shape, size and with homogeneous size distribution.