Sex Dimorphism in Spinal glial Signaling in Pathological Pain

Ya-Yu Zhao, Ying Fei, Hui C

Abstract

Following painful stimuli and injuries, activated microglia and astrocytes contribute to the facilitation of pain signaling via glia-neuronal signaling pathway. The purpose of this mini-review is to compare recent progress of the last 5 years on microglia and astrocyte control of pain, especially sex differences in pathological pain.