Simple and sensitive CE method for simultaneous determination of ofloxacin and cefixime in their combined dosage form

Ahmed O. Alnajjar

Abstract

The proton ligand dissociation constants of some Schiff bases of pyrazole aldehyde and the stability constants have been determined in DMF/THF-water (60:40 v/v) medium at 308.15 K. using Bjerrum-Calvin pH titration as extended by Irving and Rossotti. The stability constants are related to dissociation constants of these ligands, which depends on the substituents attached to the organic moiety.