Original Article
A. Kottai Muthu, T. Rattaiah G
Abstract
Orthogonal polynomial function method has been developed for the simultaneous estimation of binary mixtures of Amlodipine and Atorvastatin in tablet formulations. All the parameters for orthogonal polynomial function method have been optimized by using computer programme in “C” language. The described method was applied for the determination of these combinations in synthetic mixtures and tablet dosage forms. The contents of amlodipine in tablets were found to be 2.49 mg and Atorvastatin is 9.96 mg of the label claim 2.5 mg of amlodipine and 10 mg of Atorvastatin respectively. The linearity was validated by least square method. The recovery is within the limit of 98% to 102%. The proposed methods are simple, economical, accurate, reproducible and rapid.