SiO2-H3PO4catalyzed solvent free aldol condensation: Synthesis and spectral correlations of some antimicrobial potent arylE2-propen-1-ones

Perumalsamy Janaki, Krishnamoo

Abstract

Some substituted styryl 4-ethylphenyl ketones have been synthesised using solvent free SiO2-H3PO4 catalyzed aldol condensation between 4- ethylphenyl methyl ketone and substituted benzaldehydes under microwave irradiation. The yields of the ketones are more than 85%. The synthesised chalcones were characterized by their analytical, physical and spectroscopic data. The spectral frequencies of these ketones have been correlated with Hammett substituent constants, F and R parameters using single and multi-linear regression analysis. The antimicrobial activities of these ketones have been studied using Bauer-Kirby method.