Original Article
Gopal Kakade, Balaji Madje, Ma
Abstract
An efficient Hantzsch condensation of polyhydropyridopyrimidine derivatives was reported via a four-component coupling reaction of aldehydes, barbituric acid, ethyl acetoacetate and ammonium acetate in the presence of H2NSO3H under solvent-free conditions. Operational simplicity, use of a reusable, economically convenient catalyst under solvent-free condition is described in this paper.