Spectrophotometric Methods for the Determination of Cefprozil in Bulk and Its Pharmaceutical Formulations

C. Ramesh, G. Nagarjuna Reddy,

Abstract

Three visible spectrophotometric methods have been described for the assay of cefprozil either in bulk form or dosage forms. Methods A-C is based on the oxidation of cefprozil with an excess of oxidant [N-bromosuccinimide (NBS) in methods A & B or chloramine-T (CAT) in method C] in acidic medium. The unreacted oxidant is then estimated colorimetrically by using an oxidisable dye [Celistine blue (CB) in method A or Gallocyanine (GC) in method C] or by p-N-methylaminophenol sulphate (PMAP)- sulphanilamide (SA) reagent in method B. Regression analysis of Beer’s law plots showed good concentration range 4.0-20.0 μg/mL, 4.0-20.0 μg/mL and 1.0-10.0 μg/mL for methods A, B and C, respectively and gives reproducible results.