Studies on Imidazole and Its Derivatives with Particular Emphasis on Their Chemical/biological Applications as Bioactive Molecules/Intermediated to Bioactive Molecule

Munish kumar, Deepak Kumar

Abstract

Imidazoles are heterocycles with five-member ring structure heterocyclic compounds have gained very remarkable place in recent years because of their exceptional pharmacological activities. The imidazole nucleus is a main synthetic strategy in drug discovery. Imidazole is a planar five-member ring system having N atom at 1 and 3 positions. The systemic name for the compound is 1, 3 diazoles, one of the N bear an H atom and other to be termed as a pyrrole type N. Imidazole was first named as glyoxaline. It is amphoteric in nature, and it has susceptibility to be attacked by electrophile and nucleophile. It is a constituent of the purine nucleus and histidine amino acid, 4-amino imidazole-5- carboxamide found naturally as a riboside. This interesting group of heterocyclic compounds has wide range biological activities such as, analgesic, anti-inflammatory anticancer, antiviral, anthelmintic, anticonvulsant, antiulcer, antimicrobial, anti-allergic activity etc. Various methods employed for the synthesis of imidazole’s and their chemical structure reactions offer enormous scope in the field of medicinal chemistry.