Supramolecular Chemistry: An Alternative Approach to Improve Potential Active Pharmaceutical Ingredient’s (APIs)

Renu Chadha and Dimpy Rani

Abstract

Supramolecular interactions in the solid state of a crystalline from plays a vital role in controlling of its physicochemical properties. The tailoring of these non-covalent interactions, in already established APIs can be utilized to design a new chemical entity with improved biopharmaceutical properties. This review article throws the light on the supramolecular chemistry in different crystalline forms (polymorphs, cyclodextrin complexes, salts and co-crystals) and how the supramolecular architecture has contributed for the betterment of the potential APIs.