Syntesis and Aticonvulsant Activity of Mannich Bases and Unsaturated Amides : Role of Hydrogen Bonding

S. N. Pandeya, U. K. Singh, J.

Abstract

Some Mannich bases of camphor and menthone have been prepared. p-chloroacrylamide derivatives have also been synthesized. The compounds have been screened for their anticonvulsant activity in MES and ScDTZ tests. Structures possessing H-bonding sites were found to be active.