Research Article
K. H. Patel and A. G. Mehta
Abstract
Novel series of heterocyclic compounds [(4-(2-naphthalenyl) thiazol-2-yl)-2-(substituted phenyl)-6-phenyl- 4-thioxo- 1,3,5-oxadiazine (4a-h) have been synthesized by condensation of Schiff bases Arylidine-[4-(2- naphthalenyl)thiazolyl]-2-amines (3a-h) with benzoyl isothiocyanate. Synthesized heterocyclic compounds were characterized by elemental analysis, NMR, CMR and FTIR spectral features. Antifungal activities of all the compounds were studied against various fungi. Compounds 4e and 4h showed good antimicrobial activity. Other compounds showed moderate activity compared to standard drugs against bacterial strains