Synthesis and antimicrobial activity of 1-(aroyl/aryl sulpho/arylamino methyl)-4-[4,4-difluoro diphenyl)-methyl]-piperazines

M.D.Savaliya, J.G.Dobaria , V.

Abstract

1-Aroyl-4-[(4,4-difluorodiphenyl)-methyl]-piperazines(3a-3j);1- Arylsulpho-4-[(4,4-difluorodiphenyl)-methyl]-piperazines (4a-4j); 1- Arylaminomethyl-4-[ (4,4-difluorodiphenyl)-methyl]-piperazines(5a-5j) have been synthesized. The products have been assayed for their antimicrobial screening against Gram+ve, Gram–ve becteria and fungi. Some of the products showedmoderate activity compare with known standard drugs viz. ampicillin, chloramphenicol, norfloxacin and griseofulvin at same concentration 50ìg. The structures of the products have been elucidated by IR, 1HNMR, Mass spectral data and elemental analysis.