Synthesis and Antimicrobial Activity of N-Lactosylated Dithiazolidine (Hydrochlorides)

Sharayu M. Thorat and Shirish

Abstract

A series, 4-aryl-5-hepta-O-acetyl-β-D-lactosylimino-3-hepta-O-acetyl-β-D-lactosylimino-1, 2, 4- dithiazolidine (hydrochlorides) have been synthesized by the interaction of 1-hepta-O-acetyl-β-D-lactosyl- 3-aryl thiocarbamides and N-hepta-O-acetyl-β-D-lactosyl-S-chloro isothiocarbamoyl chloride. The title compounds were characterized on the basis of elemental analysis and IR, NMR and Mass spectral studies. The title compounds exhibited comparable antimicrobial activities against different pathogens.