Synthesis and antimicrobial activity of novel 1,2,4-triazole derivatives

Veena Vani Kotla and Venkata R

Abstract

The title compounds were synthesized by cyclization of 1-(2-(3-chloro-4-methyl-2-oxo-2H-chromen-7-yloxy)acetyl)- 4-substituted phenyl thiosemicarbazides (5a-i) in alkaline medium. Compounds (5a-i) were obtained by the reaction of 2-(3-chloro-4-methyl-2-oxo-2H-chromen-7-yloxy)acetohydrazide (3) with substituted phenyl isothiocyanates. The newly synthesized compounds were characterized by 1H NMR, IR and Mass spectral data. Further all the compounds were screened for antibacterial activity against Bacillus substilis, Escherichia coli, Pseudomonas aeruginosa and antifungal activity against Aspergillus niger and Aspergillus flavus.