Synthesis and Antimicrobial Activity of Pyrazolyl Triazoles

Research Article

Gaddam Lakshmi Teja, Dontha

Abstract

Pyrazolyl triazoles (5) were prepared by 1,3-dipolar cycloaddition of diazomethane to Schiff base - 3-ethynyl- N-(heteroarylmethylene)aniline (3), followed by oxidation with I2 in DMSO and studied their antimicrobial activity. The pyridine and dichloropyridine substituted compounds 3d, 5c and 5d are potential antibacterial agents against Bacillus subtilis and 3d is a potential antifungal agent against Penicillium chrysogenum.

Relevant Publications in Medicinal Chemistry