Research Article
Raghav Mishra, Isha Tomer, Pri
Abstract
Thiazole nucleus has been established as the potential entity in the largely growing chemical world of heterocyclic compounds possessing promising pharmacological characteristics. A series of pyrazoline thiazole derivatives were synthesized with an objective to develop novel and potent antimicrobial agents of synthetic origin. The required starting material 2-amino-4-aryl thiazole (1) was synthesized via a multicomponent condensation between thiourea, acetophenone and bromine. The Compound 1 was reacted with p-chloroacetophenone and various substituted aldehydes to synthesize the intermediates (3a- 3d) which on cyclization with hydrazine hydrate yielded final products i.e. pyrazoline thiazole derivatives (4a- 4d). Synthesized compounds were purified, characterized and evaluated for their antimicrobial activity. Most of the compounds exhibited moderate to significant activities.