Synthesis and biological screening of 2-(4-chlorophenyl)-6-methyl-3-(3- aryl -1-acetyl/phenyl -4,5-dihydropyrazol-5-yl)- imidazo[1, 2-a]pyridines

V.V.Bhuva, V.N.Patolia, A.U.Pa

Abstract

2-(4-chlorophenyl)-6-methyl-3-(3-aryl-1acetyl-4,5-dihydropyrazol-5- yl)imidazo [1,2-a] pyridines (4a-4l); 2-(4'-chlorophenyl)-6-methyl-3-(3-aryl- 1-phenyl-4,5 dihydropyrazol-5-yl) imidazo [1, 2-a] pyridines(5a-5l) have been synthesized. The products have been assayed for their biological activity against Gram +ve,Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50g/ml. The structures of the products have been elucidated by IR, 1HNMR, Mass spectral data, elemental analysis and thin layer chromatography.