Synthesis and biological studies of N-(3-chloro-2-aryl-4-oxoazetidin-1-yl)-2-(5-((naphthalen-1-yloxy)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetamide

Ashok Prasad,K. S. Nimavat and

Abstract

2-(5-((Naphthalen-1-yloxy)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl) aceto hydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding N'-arylene-2-(5-((naphthalen-1- yloxy)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetohydrazide (2a-h) in good yield. Cyclocondensation of compounds (2a-h) with chloro acetyl chloride yields N-(3-chloro-2-aryl-4-oxoazetidin-1-yl)-2-(5- ((naphthalen-1-yloxy)methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetamide (3a-h). The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.