Synthesis and Characterization of Some Novel 2-pyrazoline Derivatives and Study of their Antibacterial Activity

Mamta Ahuja and Ravi Sethi

Abstract

A new series of 1-Acetyl-5-(4-nitrophenyl)-3-(2-thienyl/pyridinyl/phenyl)-2-pyrazoline were synthesized by reacting 3-(4-nitrophenyl)-1-(2-thienyl/pyridinyl/phenyl)-2-propene-1-one (chalcones) with hydrazine hydrate in acetic acid. All the prepared compounds were characterized by spectral data (IR, 1H NMR) and microanalysis. All the synthesized compounds were also evaluated for their antibacterial activity against Gram +ve and Gram -ve bacteria