Synthesis and Cytotoxic Screening of Fused Analogues of Dihydropyrimidinones against Hepg2 Cancer Cell Lines

Richard Soni, Ramandeep Kaur B

Abstract

10In the past decades, Biginelli-type dihydropyrimidones have received an extensive attention due to their interesting pharmacological properties with heterocyclic scaffolds. In this article, we have synthesized a series of fused analogues of Biginelli’s dihydropyrimidinone derivatives (RS-6 to RS-15). IC50 values of synthesized compounds against the proliferation of human hepato cellular carcinoma (HepG2) cell lines were determined through MTT assay. Compounds RS-10 (IC50=87 ± 0.2 μg/mL) & RS-15 (IC50=78 ± 3.7 μg/mL) showed most potent activity. Also compounds RS-7 (IC50=124 ± 3.2 μg/mL) & RS-12 (IC50=128 ± 1.9 μg/mL) showed significant cytotoxic activities against HepG2 cancer cell lines.