Synthesis and evalution of some newer indole derivatives as anticonvulsant agents

Neha Garg, Trilok Chandra, Sum

Abstract

Anewseries of 3-(1-(3”-(Substitutedphenyl-5”-mercapto-1”,2”,4”-triazolyl)- 2’-oxo-3’-(2-chlorophenoxy)-1-azetidinoyl)-4’-indoles (6a-e)was synthesized for anticonvulsant activity. Compound (6c) found to be most potent compound of this series. All compounds were screened in vivo for their anticonvulsant activity and acute toxicity studies. The structural assignment of these compounds has been made on the basis of elemental analysis, IR and 1H-NMR and Mass spectroscopic data.