Synthesis and invitro evaluation of novel benzoxazole derivatives as specific cyclooxygenase – 2 inhibitors

Srinivas Ampati* , J. V. Vidy

Abstract

We have synthesised a series of methyl-2-{(2-(dialkylamino) acetamido)}-benzoxazole-5- carboxylates from Methyl 3-amino-4-hydroxybenzoate and investigated their ability to inhibit human cyclooxygenase-2 enzyme (COX-2). The IC50 values of Compounds Compound VIIf and Compound VIIb were found to be comparable to that of standard - refecoxib. Thus, this class of compounds apart from the ease of synthesis and higher yield may serve as excellent candidates for selective COX-2 inhibition