Synthesis and screening of chromene-2-one derivatives for antipsychotic activity

Pankaj Arora*, M S Ranawat, Na

Abstract

Various Coumarin derivatives (2a-2f) were synthesized and evaluated for their antipsychotic action using Apomorphine induced behavior model, 5-HTP induced behavior model, Conditioned avoidance response model and Rota rod experiment. All compounds showed significant (P<0.05) antipsychotic activity during study and it was found that target compounds have affinity for dopamine as well as for 5-HT receptors.