Synthesis and spectral studies of noval benzyl derivative of ciprofloxacin and their Cu (II) and Co (II) complexes

Y.M. Thakre and M. D. Choudhar

Abstract

Reaction of 1-cyclopropyl-6-flouro-1, 4-dihydro-4oxo-7- (1-piperazinyl)-3quinolone carboxylic acid (ciprofloxacin) with The benzyl chloride in presence of base triethylamine,with introduction of amide group in ciprofloxacin to form new benzyl derivative of 1-cyclopropyl-6-fluoro-4-oxo-7-[4-(phenyl carbonyl) piperazin-1-yl]-1,4-dihydroquinoline- 3-carboxylic acid(Cip-d) and their Cu(II) and Co(II)complexes were established on the basis of spectral studies 1HNMR,IR,Mass spectroscopy .