Research Article
Sadaf Jamal Gilani, Kandasa
Abstract
A series of Isoninicotinic acid hydrazide (INH) incorporated derivatives of thiazolidin-4-one (2a-h, 3a-h), azetidin-2- one (4a-h) and 1,3,4-oxadiazole (5a-h) were synthesized in satisfactory yield and pharmacologically evaluated for their in vitro antifungal activity. All the synthesized compounds were in good agreement with elemental and spectral data. A majority of the tested compounds showed good to moderate antifungal activity against all tested pathogenic fungal strains. To evaluate the toxicity of the compounds on liver, estimation of enzymes was also carried out.