Research Article
P. Jagadeeswara Rao, K. S. Bha
Abstract
New novel derivatives of 2-(4-substituted phenoxy)-1, 3, 2-benzodioxa phosphole-2-oxide with 1, 3, 4 -oxadiazole System were prepared by the reaction between 2-(4-substituted phenoxy)-1,3,2-benzodioxaphosphole-4- carbohydrazide-2-oxides 3(a-e) with p-substituted acetophenone (4) yielded the corresponding 2-(4-substituted phenoxy)-N’-(1-(4-substituted phenyl) ethylidene)-1,3,2-benzodioxaphosphole-4-carbohydrazide-2-oxide 5(a-t). These were allowed to undergo cyclization to develop 2-aryl-3-acetyl-1,3,4-oxadiazole system in the presence of aceticanhydride to give corresponding final products 1-(2-(4-substituted phenyl)-5-(2-(4-substituted phenoxy)-1,3,2- benzodioxa phosphole-4-yl-2-oxide)-2-methyl-1,3,4-oxadiazole-3(2H)-yl) ethanone 6(a-t). The chemical structures of these newly synthesized compounds were characterized by 1H-NMR, Mass, IR, C13-NMR and P31-NMR Spectral data. These newly synthesized compounds 6(a-t) were screened for their antibacterial and antifungal activity