Synthesis, Characterization and Biological Activity of 2-Aryl-3-Substituted Thiazolidyl-1, 3-Thiazolidin-4-Ones from Aryl Ketones

Padmavathi P. Prabhu, D. Satya

Abstract

Substituted Schiff’s bases (VIIa-f) prepared by the treatment of 2-amino-4-phenyl thiazole with different aldehydes on cyclocondensation with thioglycollic acid (mercapto acetic acid) in dry benzene furnished a new series of 2-(substituted phenyl)-N-(substituted-4-phenyl thiazolyl)-4-thiazolidinones (IXa-f). The structure of the compounds have been assigned on the basis of elemental analysis and spectral data. The products were evaluated for their in vitro growth inhibiting activity against several microbes. Some of the compounds showed significant anthelmintic activity.