Synthesis, characterization and biological screening for antifungal, antimalarial and antitubercular activities of novel bis-imines and their metal complexes

Gayakwad DR, Sarda SR, Tekale

Abstract

Herein we report the synthesis and characterization of bisimines of ortho-vanillin and iso-vanillin with hydrazine hydrate. Further these bis-imines were used as ligands for the synthesis of metal complexes with transition metals Cu(II), Ni(II), Co(II), Fe(II), Zn(II) Mn(II) and Cd(II). The bis-imines and metal complexes were well characterized and screened for antifungal, antimalarial and antitubercular activities. Bisimines and their transition metal complexes were reported for potential antifungal, antimalarial and antitubercular activities. It is observed that metal on complex formation increased the activity as compared to ligands.