Synthesis, Characterization And Biological Screening Of novel N-[2-chloro-4-(trifluoromethyl) phenyl] 4-(substituted phenyl)-6-methyl-2-thioxo-1, 2, 3, 4- tetrahydropyrimidine-5-carboxamide

Nitesh Chauhan, Kiran Nimavat

Abstract

Synthesis of novel N-[2-chloro-4-(trifluoromethyl) phenyl]-4-(substituted phenyl)-6-methyl-2-thioxo-1,2,3,4- tetrahydropyrimidine-5-carboxamide (4a-o) was achieved by acid catalysed cyclocondensation of N-(2-chloro-4- (trifluoromethyl)phenyl)-3-oxobutanamide(1), thiourea(2) and Substituted Benzaldehydes(3). The structures of the synthesized compounds were confirmed on the basis of spectral and elemental analysis. The synthesized compounds were screened for antimicrobial activity.