SYNTHESIS, CHARACTERIZATION AND FUNGICIDAL ACTIVITY OF KETOAZOMETHINES, 2-KETO-3-(SUBSTITUTED ARYL)-1-THIAZOLIDIN-4-ONES AND METAL COMPLEXES

ARCHANA SAXENA, SANIDHYA UPADH

Abstract

Four ketoazomethines, five 2-keto-1-thiazolidin-4-ones and six metal complexes of 2-keto-1-thiazolidin-4-ones have been synthesized and characterized. These compounds are tested for antifungal activity against four hazardous agriculture fungi, fusarium oxyspourm, pythium, sclerotium, alternaria brassicola. All the new products exhibited considerable activity only against Fusarium but benzoylmethyl ketoazomethine and Fe (III) complex of phenylamidomethylketo-2-(2-hydroxy phenyl)-1-thiazolidin-4-one showed highest fungicidal activity (65-70%) as compared to others. Fifteen compounds are reported in this communication.