Synthesis of new dihydropyridazin-3(2H)-ylidene)hydrazine carbothioamide derivatives as an antituberculosis agent

Pratima P. Mogle, Rahul D. Kam

Abstract

A series of new carbothioamide derivatives containing pyridazine ring have been synthesized by acid catalyzed condensation of thiosemicarbazide with corresponding substituted pyridazinone. The compounds have been characterized by IR, NMR and spectral analysis. All the synthesized compounds are evaluated for antituberculosis activity. Some of these derivatives are found to be active against the Mycobacterium tuberculosis H37Ra (MTCC 300).