Synthesis of novel bridgehead heterocycles via cyclization of 4-amino-1,2,4- triazole-3(4H)-thiones and their antimicrobial screening

Naqui Jahan Siddiqui, Mohammad

Abstract

Synthesis of new fused heterocycles (1a-d to 5a-d) by the interaction of (4-amino-5-(5-(substituted/unsubstituted benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)-2H-1,2,4-triazole-3 (4H)-thiones (a-d) with dissimilar reagents. Constitutions of the title compounds have been established on the basis of chemical transformations, elemental analysis, IR, 1H NMR, 13C NMR and Mass spectral studies. In addition the invitro antibacterial and antifungal properties were tested for these synthesized compounds compared with Ampicillin and Clotrimazole as reference drugs. Most of the synthesized compounds were found to possess moderate to excellent activity against selected strains.