Synthesis of substituted pyrazole derivatives and evaluation of their antimicrobial activity

Mehta Hardik Ashokbhai, Parmar

Abstract

Cyclization of substituted phenyl hydrazine with EAA was done to get pyrazolone derivatives. It were further reacted with various substituted benzoyl chlorides to get substituted pyrazole moiety. The structure of the synthesized compounds has been assigned on the bases of spectral studies. The compounds were evaluated for microbial screening against Gram positive & Gram negative bacteria and fungal strain. Most of the compounds show significant activity against all the spices of bacteria and fungi.