Synthesizes and Antimicrobial Evaluation of some Novel Heterocyclic Compounds

Tarun M. Patel and Amit M. Pat

Abstract

4-(1H-naphtho[1,8-de][1,2,3]triazin-1-ylsulfonyl)aniline (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4-(1H-naphtho[1,8-de] [1,2,3]triazin-1-ylsulfonyl)-N-arylideneaniline (2a-d) in good yields. cyclocondensation of compounds (2a-d) with thioglycolic acid 3-(4-(1H-naphtho[1,8-de][1,2,3]triazin-1- ylsulfonyl)phenyl)-2-arylthiazolidin-4-one (3a-d). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.