Targeting Hypertension to Manage Alzheimer's Disease: Rational and Promise

Cifuentes D, Pasteur-Rousseau

Abstract

Epidemiological, clinical and experimental animal studies uncover the close and complex interaction between Alzheimer’s disease and hypertension, a major risk factor for cardiovascular disease and stroke. Here we overview recent evidences on the impacts of both conditions on cerebral vasculature and discuss the ways in which hypertension may contribute to the onset and progression of Alzheimer’s disease.