The influence of insulin resistance on very low-density lipoprotein proteome changes in type 2 diabetes after oral high-fat meal loading: A pilot study

Siriporn Sangsuthum1, Winai Da

Abstract

Insulin resistance plays a role in diabetic dyslipidaemia, especially postprandial hypertriglyceridaemia, through the overproduction of very low-density lipoprotein (VLDL). However, the role of insulin resistance on the apoprotein profile of VLDL has not been explored. To study the influence of insulin resistance on the VLDL proteome in the fasting and postprandial states. Eleven type 2 diabetes (T2DM) subjects with moderated metabolic control (HbA1c