The Second Messengers Ca2+ and cAMP as Potential Therapeutic Targets for the Control of Cancer Progression

Paolo Ruggero Errante, Francis

Abstract

This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on the cell metabolism of cyclic nucleotides such as cAMP, and on the intracellular Ca2+ signaling, which may avail the reduction of toxic effects promoted by chemotherapy, radiotherapy and immunotherapy, thus decreasing the incidence of interruption in antitumoral treatment.

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