Thiazole and thiadiazole: A promising moeity for antimicrobial activity

Amit Chawlaa,b*, Payal Chawlab


Heterocyclic compounds have a special place in pharmaceutical field. The remarkable ability of heterocyclic nuclei to serve both as biomimetics and reactive pharmacophores has largely contributed to their unique value as traditional key elements of numerous drugs. A wide range of thiazole and thiadiazole heterocyclic ring system has been studied for the development of novel chemical entities as a lead molecule in the drug discovery paradigm and these moieties can be found in a large number of compounds which display biological activity. The biological activity of the compounds is mainly dependent on their molecular structures and these both of nucleus are well known antimicrobial agents. Since the beginning of the search of medicinally important synthetic compounds heterocyclic chemistry always remained the point of attraction because of their diverse biological properties. Substitution of heterocyclic compounds on various positions produced medicinally important analogues which are used in the treatment of various diseases.

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