Treatment of moderate-to-serious plaque psoriasis regularly requires the utilization of phototherapy or fundamental treatment, which incorporates immunosuppressants, retinoids, and biologic specialists. Albeit biologic use is getting progressively well known, it isn't extraordinary for patients to encounter treatment disappointment. We portray a patient who had an imperfect reaction to etanercept monotherapy following twelve weeks of enlistment dosing (50 mg twice week after week), just as to a mix of etanercept (50 mg once week by week upkeep dosing) and narrowband bright B (NB-UVB) phototherapy multiple times week by week for an extra twelve weeks. Perceptible improvement was noted after the expansion of NB-UVB and the patient's promising reaction to phototherapy impacted further administration. Etanercept and NB-UVB were ceased and the patient was started on excimer laser medicines twice week after week. Following a month, the patient had a 75 percent decrease in Psoriasis Area Severity Index (PASI) score and following 7 weeks had more than 95 percent leeway of psoriasis. The special properties of the excimer laser may represent its clinical viability in our patient just as in different instances of obstinate psoriasis. We suggest that the excimer laser be considered in instances of biologic or regular phototherapy disappointment notwithstanding being a standard treatment choice or subordinate for the treatment of psoriasis.