Case Report
Jinyun Chen, Dandan Wang, Xia
Abstract
Most lower extremity ulcers in patients with rheumatoid arthritis (RA) will become chronic non-healing ulcers without treatments. However, established therapies, including glucocorticoid and immunosuppressive agentsdidn’t show a good efficacy. Some studies have shown umbilical-cord-derived mesenchymal stem cells (UC-MSCs) could accelerate the healing of cutaneous wounds in mice. But no clinical trials of UC-MSCs in cutaneous wound healing have been reported in human. Here we found that UC-MSCs transplantation promoted the healing of ulcers in a RA patient who underwent no improvement with established therapies. This case showed the prospective of UC-MSCs’ application in treating recurrent ulcers in RA patients.